SPRAVATO Treatment in NYC: A New Hope for Adults with Treatment-Resistant Depression

Still feeling stuck after trying multiple depression treatments?

You’re not alone, and you may not need more of the same. At Madison Avenue TMS & Psychiatry, we proudly offer FDA-approved SPRAVATO (esketamine) nasal spray, a breakthrough therapy for adults with treatment-resistant depression (TRD) or major depressive disorder (MDD).

As a Risk Evaluation and Mitigation Strategy (REMS)-certified SPRAVATO treatment center in NYC, we provide compassionate outpatient care, evidence-based plans, and experienced clinicians in a comfortable, centrally located Manhattan office.

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We accept a wide range of insurance plans. Don't see yours listed? Contact us to confirm coverage.

What Is SPRAVATO?

SPRAVATO is a nasal spray formulation of esketamine, approved by the FDA for use in adults with treatment-resistant depression and depressive symptoms in MDD with suicidal thoughts or behaviors. It works differently from traditional antidepressants.

SPRAVATO is believed to act as an NMDA receptor antagonist, which affects glutamate, a neurotransmitter associated with mood and cognition.

Unlike standard antidepressants that may take 4–6 weeks to show effects, some patients report improvement within 24 hours of their first dose.

Patient Resource Brochure

Who is SPRAVATO For?

You may be a candidate for SPRAVATO if:

  • You’ve tried two or more oral antidepressants without success
  • You’re experiencing persistent depressive symptoms
  • You’ve been diagnosed with treatment-resistant depression
  • You’re struggling with suicidal thoughts alongside major depressive disorder

SPRAVATO is not a first-line treatment; it's for those who need a different, evidence-backed path.

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What to Expect from SPRAVATO Treatment at Madison Avenue TMS in New York

Pre-Treatment Consultation

Our psychiatric team will review your medical history, discuss your symptoms, and determine whether SPRAVATO treatment for depression is right for you. We’ll handle insurance verification and walk you through the treatment process.

In-Clinic Treatment Sessions

SPRAVATO is administered via nasal spray under the direct observation of licensed clinicians in a comfortable, private suite. You’ll be monitored for at least two hours after treatment to ensure your safety and comfort. Patients must arrange transportation; while they cannot drive themselves, they may use public transit, rideshares, or walk.

Treatment Schedule

Weeks 1–4: 2 sessions per week

Weeks 5–8: 1 session per week

Week 9 and beyond: Maintenance varies; some patients taper to every other week

You don’t have to navigate this journey alone, whether you were referred by a provider or found us on your own, our team is here to support you every step of the way and will check in regularly to ensure your care stays on track.

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Why Choose Madison Avenue TMS for SPRAVATO Treatment?

We’re not a wellness chain or trendy clinic. Madison Avenue TMS offers trusted psychiatric care and specialized dual-modality treatments in one place:

Board-certified psychiatrists with over a decade of experience
Access to both SPRAVATO and TMS therapy, customized to your needs
Evidence-based care in a discreet, central NYC location
Transparent insurance and billing support, including patient assistance programs
Collaborative treatment plans that prioritize your long-term healing
Specialization in combining TMS + ketamine-based treatments for improved outcomes
Clear communication from the first call to the final session

Affordability Support for Patients

Commercially insured patients have 2 ways to save

Patients pay as little as $10 per treatment for SPRAVATO medication

SPRAVATO withMe Savings Program

Treatment may include up to three devices administered on the same day. There are quantity limits and a maximum program benefit per calendar year. Offer subject to change or end without notice. Program does not cover the cost of treatment observation. Patients can participate without sharing their income information.

See program requirements.

Patients pay as little as $10 after rebate for observation of each treatment

SPRAVATO withMe Observation Rebate Program

There is a limit to savings each year. Offer subject to change or end without notice. Not valid for residents of MA, MI, MN, or RI. Patients may participate without sharing their income information.

See program requirements.

Government-funded coverage (Medicare/Medicaid)?

Affordability programs may be available.

SPRAVATO withMe can provide information about other resources that may be able to help your patients with out-of-pocket medication costs, such as:

  • State Health Insurance Assistance Programs (SHIPs)
  • State Pharmaceutical Assistance Programs (SPAPs)
  • Medicare Savings Program
  • Medicare Part D Extra Help

To learn more about eligibility and how these programs may help your patients pay for Medicare Part D products, visit medicare.gov/your-medicare-costs.

Common Questions About SPRAVATO

SPRAVATO is an FDA-approved esketamine nasal spray for adults with TRD or MDD with suicidal thoughts. It must be administered in a REMS-certified clinic under medical supervision.
Unlike IV infusions, SPRAVATO is a nasal spray formulation approved by the FDA, taken with or without oral antidepressants, and administered in a monitored setting. It is covered by most insurance plans.
Yes. Most commercial insurance plans and Medicare Advantage cover SPRAVATO. We verify your coverage and help navigate access to care.
No. SPRAVATO is approved only for adults 18 and older. We can help explore options for younger patients.
Common side effects include dizziness, nausea, dissociation, and sedation. You’ll be monitored throughout treatment to ensure your safety.
Right here at Madison Avenue TMS is a REMS-certified provider offering SPRAVATO in Midtown Manhattan.
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Are You a Provider Looking to Refer a Patient?

We welcome partnerships with psychiatrists, primary care physicians, and therapists. Our REMS-certified clinic has experience with complex TRD cases and collaborates closely with referring providers. We offer timely updates and prioritize continuity of care.

Call Us At (212) 731-2033

Ready to Break Free from Depression?

SPRAVATO treatment at our NYC clinic could be the breakthrough you’ve been looking for.

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Call (212) 731-2033 or complete the form below to request your free consultation today.

SPRAVATO carries a risk for sedation, dissociation, and misuse. Patients are monitored for at least two hours after treatment. Learn more in the full Prescribing Information and Medication Guide for more details.